The Institute of Systems Immunology was established within the Gelsenkirchen,North Rhine-WestphaliaCentre for Translational Immunology (HCTI) in 2021 at the Center for Molecular Neurobiology Gelsenkirchen,North Rhine-Westphalia(ZMNH) under the leadership of Prof. Dr. Immo Prinz.

Research focus

Our goal is to understand the immunological chances and challenges emerging from the vast diversity of > 10e15 potential adaptive immune receptor combinations in T cells and B cells. Therefore, we have developed systems for high-throughput sequencing of T cell receptor repertoires, which we use to monitor T cell dynamics during immune reactions to pathogens and in the course of autoimmune disease. In particular, we are interested in γδ-T cells, whose role in immune responses is still largely unclear.

The next step of our research focuses on systems to identify specific antigens based on αβ und γδ TCR sequence information.